Neurobiology of ADHD and comorbid substance use disorders

Neurobiology of Adolescent Substance Use Disorders.

There are many facets of the neurobiology of substance use that are distinct in adolescence as compared with adulthood. The adolescent brain is subject to intense subcortical reward processes, but is left with an immature prefrontal control system that is often unable to resist the pull of potentially exciting activities like substance use, even when fully aware of the dangers involved. Peer in...

ADHD with comorbid substance use disorder: review of treatment

Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder that affects 3–7% of children (Wilens 2004). Prospective longitudinal studies show persistence of the disorder in 10–20% of adults diagnosed with ADHD in childhood, and a further 40–60% of patients experience partial remission, with persistence of some symptoms and significant clinical impairments (Barkley 2008). P...

Responding to comorbid mental disorders and substance use disorders

Comorbidity of mental disorders and substance use disorders is common. Furthermore, comorbidity is often associated with poor treatment outcome, severe illness course, and high service utilisation. This presents a significant challenge with respect to the identification, prevention and management of people with comorbid disorders. The unmet need for treatment within this group is considerable, ...

Treating Adolescents for Substance Use and Comorbid Psychiatric Disorders

Comorbid substance use disorders in schizophrenia: a latent class approach.

Schizophrenia is a complex psychiatric disorder with a characteristic disease course and heterogeneous etiology. While substance use disorders and a family history of psychosis have individually been identified as risk factors for schizophrenia, it is less well understood if and how these factors are related. To address this deficiency, we examined the relationship between substance use disorde...